Effect of intraarticular hyaluronan injection in experimental canine osteoarthritis
نویسندگان
چکیده
منابع مشابه
Synovial pathology in an ovine model of osteoarthritis: effect of intraarticular hyaluronan (Hyalgan).
OBJECTIVES Published scoring methods for quantifying synovitis focus on acute inflammatory parameters, and are unsuitable as outcome measures in experimental surgical models of osteoarthritis (OA). The aim of the present study was to define a modified histopathological scoring system for ovine synovium more suited to the chronic pathology induced by ovine meniscectomy, and to apply it to detect...
متن کاملAntiinflammatory and chondroprotective effects of intraarticular injection of adipose-derived stem cells in experimental osteoarthritis.
OBJECTIVE In experimental collagenase-induced osteoarthritis (OA) in the mouse, synovial lining macrophages are crucial in mediating joint destruction. It was recently shown that adipose-derived stem cells (ASCs) express immunosuppressive characteristics. This study was undertaken to explore the effect of intraarticular injection of ASCs on synovial lining thickness and its relation to joint pa...
متن کامل(Orthovisc) in osteoarthritis of the knee: a randomized, controlled, multicenter Clinical effects of intraarticular injection of high molecular weight hyaluronan
Objective. To evaluate the efficacy and safety of injection of high molecular weight (HMW) hyaluronan (Orthovisc®) in patients with mild, moderate, and severe knee osteoarthritis (OA). Methods. A randomized, arthrocentesis-controlled, multicenter trial. Patients (n = 372) were randomized to 4 weekly HMW hyaluronan injections (O4, n = 128), 3 weekly HMW hyaluronan injections followed by one arth...
متن کاملIntraarticular injection of hyaluronan prevents cartilage erosion, periarticular fibrosis and mechanical allodynia and normalizes stance time in murine knee osteoarthritis
INTRODUCTION Intraarticular hyaluronan (HA) is used clinically for symptomatic relief in patients with knee osteoarthritis (OA); however, the mechanism of action is unclear. In this study, we examined the effects of a single injection of HA on joint tissue pathology, mechanical allodynia and gait changes (measured by stride times) in a murine model of OA. METHODS OA was induced in the right k...
متن کاملeffect of intraarticular injection of ozone on inflammatory cytokines in knee osteoarthritis
introduction: knee osteoarthrosis is one of the most debilitating diseases. prolotherapy includes intraarticular injection of various drugs to decrease inflammation. injection of intradiscal o2-o3 has reduced pain and disability of patients with low back pain due to prolapsed lumbar disk. objective: to compare the effect of intraarticular injection of ozone and steroids in improvement of clinic...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 1998
ISSN: 0004-3591,1529-0131
DOI: 10.1002/1529-0131(199806)41:6<976::aid-art4>3.0.co;2-r